London (AFP) – The eyes of the world will be on Manchester this weekend as Jose Mourinho and Pep Guardiola bring their bitter feud to the Premier League for the first time.

Any derby between Manchester United and Manchester City is guaranteed to be an explosive affair, but the presence of sworn enemies Mourinho and Guardiola should ensure the animosity levels are higher than usual on Saturday.

With City top of the table and United just behind them in third after both won their first three league games, there was already more than local bragging rights at stake in a showdown between two sure-fire title contenders.

Even City midfielder Fernandinho’s boast that “this game is big, man. It’s a game that stops the city” doesn’t do justice to a fixture reported to be the richest match in football history with more than £600 million ($790 million, 708 million euros) of world-class talent on parade.

Yet, despite the presence of Paul Pogba, David Silva, Zlatan Ibrahimovic and a host of other stars, it’s the action on the Old Trafford touchline that will be must-see TV for millions around the world as United manager Mourinho and City boss Guardiola lock horns for the first time in three years in the 17th instalment of their acrimonious rivalry.

The sight of Mourinho and Guardiola gesticulating and exhorting their players signals the resumption of a complicated relationship that has turned increasingly ugly since they first met at Barcelona two decades ago.

Mourinho’s constant jibes at Barcelona boss Guardiola during his time at Real Madrid undoubtedly got under the Spaniard’s skin, but the Portuguese coach’s record of just three wins in their 16 meetings is a significant blemish on his otherwise glittering CV.

Although Guardiola has come out on top seven times against Mourinho, he goes into the derby at a significant disadvantage following City striker Sergio Aguero’s three-match ban for elbowing West Ham United’s Winston Reid.

Leroy Sane could deputise for Aguero, who had already scored six times this season, after the Germany winger returned from the hamstring injury that delayed his debut after his £37 million ($48 million, 43 million euros) move from Schalke.

– Super-fast –

Guardiola must also decide whether to give a debut to Chile goalkeeper Claudio Bravo, who arrived from Barcelona to replace the exiled Joe Hart, or stick with stand-in Willy Caballero.

“I’ve played in derby games in Germany but this should be a great match and one I’m really looking forward to, especially because Pep Guardiola is taking on Jose Mourinho,” Sane said.

Aguero’s absence will make it even harder for City to break a defence marshalled by Ivory Coast centre-back Eric Bailly, who has caught the eye of United goalkeeper David de Gea since his pre-season move from Villarreal.

“Bailly was a great signing, he’s come in and surprised us all very quickly.” De Gea said.

“I remember when I first came to England and, trust me, it can be hard early on but he’s flying.

“He is physical, strong, technically confident and super-fast.”

At the Emirates Stadium, Arsenal manager Arsene Wenger could give debuts to deadline day signings Shkodran Mustafi, a £35 million Germany defender from Valencia, and Lucas Perez, a £17 million Spanish forward from Deportivo La Coruna, as the Gunners face Southampton.

“He is uncomfortable to play against. He has everything a striker needs,” Mustafi said in defence of the unheralded Perez, whose arrival was greeted with indifference by Arsenal fans hoping for a higher-profile recruit.

Chelsea, in second place with a 100 percent record, travel to Swansea City with David Luiz set to feature after rejoining the club in an unexpected deadline day switch from Paris Saint-Germain.

Luiz was sold by Chelsea to PSG in 2014, but new Blues boss Antonio Conte sanctioned the error-prone Brazilian’s return as he grew increasingly desperate for defensive reinforcements.

“He’s played with Chelsea previously and he will bring a good personality,” Conte said.

Champions Leicester City could hand a debut to Algeria striker Islam Slimani, their club record £28 million signing, against Liverpool at Anfield.

England midfielder Jack Wilshere is set to make his Bournemouth debut against West Bromwich Albion after his shock loan move from Arsenal.

Fixtures (1400 GMT unless stated)

Saturday

Arsenal v Southampton, Bournemouth v West Brom, Burnley v Hull, Liverpool v Leicester (1630 GMT), Manchester United v Manchester City (1130 GMT), Middlesbrough v Crystal Palace, Stoke v Tottenham, West Ham v Watford

Sunday

Swansea v Chelsea (1500 GMT)

Monday

Sunderland v Everton (1900 GMT)