The Sardinians are eighth, just two points off the Europa League places despite being on a nine-match winless run.
Hellas Verona, in sixth, travel to Udinese after their success against Juventus, as Torino, on a run of four consecutive defeats, travel to Zlatan Ibrhaimovic’s AC Milan.
One to watch
Cristiano Ronaldo can push his scoring streak to a record-equalling 11 consecutive league games to match the mark currently held by Gabriel Batistuta and Fabio Quagliarella. The five-time Ballon d’Or winner has scored 24 goals in all competitions this season for Juventus, including 15 in the last ten league games.
38 – Points between Juventus and Brescia
18 – Lazio’s unbeaten run in Serie A
4 – Torino’s losing streak
1 – Inter’s points lead on third-placed Lazio
Fixtures (all times GMT)
Lecce v SPAL (1400GMT), Bologna v Genoa (1700), Atalanta v AS Roma (1945)
Udinese v Hellas Verona (1130GMT), Juventus v Brescia, Sampdoria v Fiorentina, Sassuolo v Parma (all 1400GMT), Cagliari v Napoli (1700), Lazio v Inter Milan (1945)
AC Milan V Torino (1945)