Jack Wilshere will miss key games for Arsenal and England after being ruled out for "a few weeks" with an ankle injury, Gunners boss Arsene Wenger has said.
The 23-year-old England midfielder's career has been punctuated by injury and now he has suffered another – a hairline crack of his left fibula.
Wilshere will miss Sunday's Premier League season opener with West Ham and is also likely out of England's Euro 2016 qualifying Group E fixtures with San Marino and Switzerland next month.
Wenger said on arsenal.com: "I had a bad surprise because it is a hairline crack in his fibula that makes him a few weeks out."
Reports suggested Wilshere could be out for around two months, but Arsenal have not put an exact timescale on the injury yet.
Wilshere missed last Sunday's Community Shield defeat of Chelsea, the Premier League champions, after suffering the injury in training the previous day.
Wenger initially said it would be a "matter of days" before Wilshere returned, but it swiftly became apparent he would miss the Hammers clash – and now the prognosis is far worse.
It is the latest worrying blow for Wilshere, who returned in May following another lengthy spell out with an ankle problem and has had numerous injuries throughout his career.
Wenger added: "There is minimal damage apart from the bone damage – there is no damage at all apart from that.
"It was a collision in training and it was all completely accidental."
Wilshere will continue to be assessed and treated by FA Cup winners Arsenal and there was no mention of whether surgery will be required or not.
Forward Danny Welbeck (knee) will also miss the opening game of the season, along with midfielder Tomas Rosicky (knee).
"We have Welbeck on a progressive recovery and Rosicky on a progressive recovery," Wenger added.
"He (Welbeck) is not too far away, but he is not ready for Sunday."
Alexis Sanchez is also unlikely to be included after winning the Copa America with Chile in early July.
"Alexis is back in training but I don't think he will be involved on Sunday, it is a bit early maybe," Wenger said.
"He came back in good fitness shape so that is quite positive, but I am not surprised by that because I can't imagine him lying around for four weeks and doing nothing. That wouldn't be him."
200+ Channels With Sports & News
- Starting price: $33/mo. for fubo Latino Package
- Watch Premier League, World Cup, Euro 2024 & more
- Includes NBC, USA, FOX, ESPN, CBSSN & more
Live & On Demand TV Streaming
- Price: $69.99/mo. for Entertainment package
- Watch World Cup, Euro 2024 & MLS
- Includes ESPN, ESPN2, FS1 + local channels
Many Sports & ESPN Originals
- Price: $6.99/mo. (or get ESPN+, Hulu & Disney+ for $13.99/mo.)
- Features Bundesliga, LaLiga, Championship, & more
- Also includes daily ESPN FC news & highlights show
2,000+ soccer games per year
- Price: $4.99/mo
- Features Champions League, Serie A, Europa League & NWSL
- Includes CBS, Star Trek & CBS Sports HQ
175 Premier League Games & PL TV
- Starting price: $4.99/mo. for Peacock Premium
- Watch 175 exclusive EPL games per season
- Includes Premier League TV channel plus movies, TV shows & more
- ‘Very happy’ Mbappe snubs Real Madrid to stay at PSG
- Lyon beat Barca to claim eighth Women’s Champions League
- Which countries are FIFA World Cup rivals?
- Rangers lift Scottish Cup trophy after Europa League heartache
- Mbappe set to snub Real Madrid and stay at PSG
- Rangers win Scottish Cup to erase Europa League heartache
- Kaizer Chiefs draw and miss out on Africa next season
- La Liga president calls Mbappe PSG deal ‘insult to football’
- Mbappe chooses to stay at PSG in Real snub: reports
- Man City’s De Bruyne voted Premier League Player of the season