He celebrated by freezing stockstill in the manner of the ‘Mannequin Challenge’ social media fad, with Walcott and Sterling joining in.
Lopetegui awarded senior debuts to Ander Herrera and Aspas in the second half, yet still the hosts advanced, Reina saving one-handed from Walcott and Nacho clearing off the line from Lingard.
When Spain did threaten, England substitute goalkeeper Tom Heaton denied David Silva and substitute Alvaro Morara, with Aspas putting the rebound over the bar in the first instance.
West Ham United left-back Aaron Cresswell won his first England cap as a late substitute, but was upstaged by Celta Vigo forward Aspas and Real Madrid midfielder Isco, his fellow entrants.
Aspas halved the deficit, drifting in from the right and curling home, before Isco atoned for an earlier miss by chesting down Dani Carvajal’s pass and squeezing a shot between Heaton’s legs.