There are moments that typically come to define an entire season, and in the Premier League this weekend, the fixture computer has churned out a pair of matches that stir memories of unhinged drama from campaigns gone by.

Those two fixtures feature prominently in our list as does an enticing clash from Germany, which will see one of the Bundesliga’s most underwhelming sides tackle one of the year’s surprise packages. In addition, there’s a vital MLS Cup clash to savor and massive game from Ligue 1, where the top two battle it out.

All kick off times are in Eastern time. Enjoy your weekend and enjoy the games!

Liverpool vs. Chelsea

Saturday, November 8, 7:45AM on NBCSN and NBC Sports Live Extra

The last time these two sides met at Anfield saw one of the most unfortunately iconic moments in Premier League history, as Gerrard’s slip helped Chelsea land a massive blow to Liverpool’s title aspirations.

This time round it’s Jose Mourinho’s men who are streaking clear atop of the Premier League, and they’ll go to Anfield expecting to pick up all three points. The Blues have showcased an attacking incisiveness to compliment their defensive diligence in the early stages of this season and although they’ve not quite been at their free-flowing best in recent games, they have spades of know-how when it comes to snatching big results.

But Anfield is never an easy place to go, and after Brendan Rodgers rested a host of his best players for Liverpool’s midweek clash with Real Madrid, the Reds supporters will be expecting an energetic display from their team. With the memories of last season’s heartbreaking result still relatively raw, expect a raucous atmosphere at Anfield too.

If Rodgers had fielded his star men at the Santiago Bernabeu, Liverpool would have come into this game with the pressure off. But suddenly, there is an expectancy for the likes of Steven Gerrard, Raheem Sterling and Mario Balotelli to come in and fire the Reds to a positive result against the league leaders. You suspect it’s a challenge Mourinho and his team will relish.

QPR vs. Manchester City

Saturday, November 8, 12:30PM on NBC and NBC Sports Live Extra

Manuel Pellegrini’s side will make the trip to London on the back of yet another disappointing European night, a game in which they lost 2-1 at home to CSKA Moscow. Next up for the champions is another difficult challenge, as they face a rapidly improving QPR team.

While Harry Redknapp’s side have lost two of the last three games, there have been undeniable improvements in the way in which the Loftus Road outfit play. A win over Aston Villa was bookended by narrow losses to Chelsea and Liverpool, and after playing with a renewed intensity in all three of those clashes, you suspect QPR will be excited by the visit of the champions.

With Chelsea making the trip to Anfield in Saturday’s early game, City may be presented with an opportunity to make up some ground in the title race. But they’ll have to turn in a display that is much improved on their efforts in midweek, as they played without ingenuity and purpose against the Russian side.

They’ll be without David Silva, but in Sergio Aguero they do possess the Premier League’s most prolific forward and a man who netted that goal against QPR back in 2012. The onus will be on him to haul City over the line in this one, but the likes of Vincent Kompany and Joe Hart but give this one their full attention too; QPR’s attacking triumvirate of Charlie Austin, Bobby Zamora and Eduardo Vargas have been a real handful for opponents in recent weeks.

D.C. United vs. New York Red Bulls

Saturday, November 8, 2:30PM on NBC & NBC Sports Live Extra

D.C United face a huge task if they’re to overhaul a two-goal deficit against New York Red Bulls in the second leg of their Eastern Conference semi-final.

After a 2-0 loss to the Red Bulls in the first leg, the onus will be on the home side to come out and attack here. But after being convincingly beaten last time out, they must play much more astutely to accrue the two goals needed to force this playoff into extra time, or the three that’d see them win the tie outright.

That’s assuming the Red Bulls don’t net of course, and with prolific goalscorers like Thierry Henry, Bradley Wright-Phillips and Tim Cahill in situ, Mike Petke will be confident that his team has enough attacking ammunition to find of the back of the net at RFK Stadium. If they do score, D.C would need to net at least four times to go through.

Henry was the star of the show in the first game, bagging two excellent assists. The former Arsenal man’s future in the MLS remains in serious doubt with his contract due to expire come the end of the current campaign, and he’ll be keen to keep his New York adventure going a little longer yet with a strong display here.

Borussia Dortmund vs. Borussia Monchengladbach

Sunday, November 9, 11:30AM on GolTV

Jurgen Klopp must have scratched his head in confusion on many occasions this season, and with his Dortmund side joint-last in the race for the Bundesliga, he’ll be desperate to his team get back to winning ways against high-flying Borussia Monchengladbach.

It’s been a hugely peculiar season at the Westfalenstadion. Dortmund won their fourth consecutive Champions League game in the week and it that competition they’ve looked absolutely sensational. But on the domestic front they’ve been deplorable, showcasing a profligacy in front of goal and a dearth of the ferocious pressing that has brought them so much success in the past.

In their last outing Die Borrusen lost 2-1 to Bayern Munich at the Allianz Arena and there were signs that they might be starting to find their feet in the early stages of the match. In Marco Reus they have a player who is in outstanding form, and after his goal against the champions, Klopp will be hoping his No. 11 can inspire Dortmund to a much needed win.

Monchengladbach have been excellent so far this season though and their brisk counter-attacking style will make them awkward opponents for Dortmund. They’re playing with a real swagger at the moment and after an prosperous start to the campaign, they’ll fancy their chances of taking all three points from the Westfalenstadion; a massive improvement will be needed from Dortmund if they’re to stop them doing so.

Paris Saint-Germain vs. Marseille

Sunday, November 9, 3:00PM on beIN SPORTS & DishWorld

Marseille’s exciting early form under the tutelage of Marcelo Bielsa will face it’s biggest test so far, when they tackle Paris Saint-Germain at the Parc des Princes.

The French champions have been in ropey form during the early weeks of the season, but they finally seem to be getting back on track. PSG have won their last three Ligue 1 matches on the bounce, and although they’ve missed the influence of Zlatan Ibrahimovic—currently out through injury—Edinson Cavani is having arguably his best run of games for the Parisians.

The Uruguayan has been shunted out to the right-hand side for the majority of his short career in the French capital, but with the effervescent Swede unavailable, he’s been given a run through the middle and Laurent Blanc is beginning to reap the rewards. Cavani has three in his last three games and looks set to lead the line against Marseille; PSG will be hoping his goals will help reduce the gap at the top to just one point.

But Marseille are a side that have been outstanding in the early weeks of the campaign, and although Lyon recently ended their magnificent eight-game winning run, Bielsa’s men got back to winning ways against Lens last time out. A triumph here would be the coupe de grace on their wonderful start, and surely cement Marseille’s status as genuine title challengers.

Follow Matt on Twitter @MattJFootball